SiliaBond Cyanoborohydride (CBH) (R66730B)

SiliaBond^® Cyanoborohydride (Si-CBH) is the silica bound equivalent of sodium cyanoborohydride. Bound cyanoborohydride is very useful in reductive amination and in the reduction of imines and aldehydes. Cyanide contamination of the product is a concern when using the solution phase equivalent. This problem is minimized with the use of silica bound materials since the toxic cyanide residue remains on the silica. Additionally, it may be used to reduce α, β-unsaturated carbonyl to the corresponding unsaturated alcohol.

To see if any cyanide ion was leaching from the silica, 1 g of SiliaBond Cyanoborohydride has been washed in 10 mL of methanol for 24 hours. Cyanide strips indicated less than 3 ppm in each test performed.

PRODUCT SPECIFICATIONS

MSDS-R66730B

APPLICATION NOTE
Reductive animation : Click here

POSTER
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RELATED PUBLICATION

1. Tet. Lett., 50 (2009) 6658
2. Tet. Lett., 50 (2009) 2552