E-PAK Screening and Optimization Services
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Scavenging screening services provide solutions to quickly develop the most efficient metal scavenging process providing both time and cost savings. Confidentiality is assured and we will be working with you, in function of your needs.
Main objective is to accelerate research, optimize production costs, while remaining fully in compliance with new regulations and environmental challenges
Scavenging strategies imply lower volumes of solvent, less person-days and higher yields by minimizing loss of product via classical purification processes
Batch: Lab and Process Development
Step 1: Screening
- Different SiliaCarb activated carbons and SiliaMetS / SiliaBond scavengers will be tested on the crude product at two different temperatures.
- Influence of contact time will also be evaluated.
Step 2: Optimization
- After this initial screening, we will select the most efficient carbon and scavenger to optimize the ratio vs the API.
- Pairwise combinations of metal scavengers could also be tested, if satisfactory results are not obtained. Scavenging yields as well as recoveries will be evaluated.
Step 3: Scale-up Confirmation and Optimization
- A new amount of crude product will then be treated with SiliaCarb (if relevant), using the best obtained conditions to get enough product to work on the next step.
- Finally, we will test the best conditions on the API solubilized in two other solvent systems (depending on API solubility and customer's requirement). Scavenging yields as well as recoveries will be evaluated.
- Best conditions will be transposed on larger scale (to be determined based on the remaining crude product).
Batch to E-PAK: Including Process Development
Includes all points performed with "batch" service plus the following:
- SiliaCarb and SiliaMetS / SiliaBond best conditions will be then transfered to E-PAK radial flow cartridges.
- Contact time’s effect can be evaluated as well as parameters optimization on E-PAK for both SiliaCarb and SiliaMetS / SiliaBond reaction.
- Scalability study based on customer final equipment can be performed if enough crude is available.
Two Plans for R&D Services
| Includes | BATCH Scavenger Screening |
BATCH TO E-PAK Scavenger Screening |
|---|---|---|
| SiliaCarb and SiliaMetS / SiliaBond screening in bulk | ✓ | ✓ |
| Optimization in different solvents | ✓ | ✓ |
| Impurity concentration tracked by ICP-MS or ICP-OES | ✓ | ✓ |
| Scale-up confirmation and optimization (will need to be confirmed by our researchers) | ✓ | ✓ |
| Transfer of the optimized conditions to E-PAK radial flow cartridge | ✓ | |
| Evaluation of contact time in E-PAK radial flow cartridge | ✓ | |
| Scalability based on customer final equipment can be performed if enough product is available | ✓ | |
| Complete report provided | ✓ | ✓ |
| Expected screening service delay after reception of customer's sample | 3 - 4 weeks | 4 - 6 weeks |
| Typical crude quantity needed (will need to be confirmed by our researchers) | 50 to 200 g of crude | 100 to 200 g of crude |
Interested in a screening service?
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