SiliaPrep SPE & Well Plates – Metal Scavengers

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SiliaPrep^™ Metal Scavengers are unique and they have significantly changed how chemists can prepare active pharmaceutical ingredients (APIs). Any synthetic pathway is now possible, even the ones using metal catalysts. Treatment with SiliaPrep Metal Scavengers will lower the residual metal concentration of various metal complexes (Pd, Pt, Rh, Ru, Ni, Sn, etc.) to single digit ppm. Ask for the SiliaPrep Metal Scavengers brochure for more information and experimental results about these products.

Typical Experimental Procedure

To find out which SiliaPrep Metal Scavenger will better suit your need, we recommend performing some screening using the SiliaPrep Metal Scavenger Kit (PN: SPE-K30730B-06U) to quickly determine which scavenger presents the highest efficiency and make experiment optimization from there.

1. SiliaPrep Metal Scavenger sorbent bed weight: use at least 4-8 eq. of the metal scavenger in respect to the residual metal concentration.
2. Column conditioning using one column volume of methanol (or appropriate solvent).
3. Sample application: add the metal containing solution to the top of the and let it pass through the SiliaPrep SPE under gravity.
4. Washing the SiliaPrep SPE with additional solution solvent for total recovery of the API.
5. Selection of the most efficient SiliaPrep Metal Scavenger by residual metal concentration analysis of each solution (the one with the lowest residual metal concentration). You can choose more than one scavenger.
6. Experiment optimization using the most efficient SiliaPrep Metal Scavenger (modify the number of molar equivalents of the metal scavenger, change the reaction time, and adjust flow rate).