In order to simplify the use and the removal of acids / bases and their salts from reaction mixtures, SiliCycle has developed a range of silica bound SiliaBond acids and bases :
SiliaBond® Glycidoxy (Si-GLY) may be used as a linker for further modification of the surface and for the immobilization of molecules bearing amino, hydroxy, mercapto and thiocarboxylic acid groups.
SiliaBond Pyridine (Si-PYR) can be used as a tertiary amine for acid removal. It can also anchor Cu2+ ions and then be used as a catalyst for hydroquinone oxidation.
SiliaBond® Dimethylamine is a silica bound tertiary amine base that can be used in most applications requiring a tertiary amine, particularly as a HCl sponge. Silica bound ammonium salt by-products are easily separated by filtration. This dimethylamine immobilized on silica gel can be used as a base catalyst in Michael or Knoevenagel reactions.
Supported sulfonic acids such as SiliaBond® Propylsulfonic Acid (SiliaBond SCX-2) are in a class of strong acids widely used in different fields of synthetic organic chemistry. Their applications are well known and are used in a large number of settings going from drug discovery laboratories up to manufacturing processes. Among these applications, we denote their uses as acid catalysts, stationary phases for ion chromatography and basic impurity scavengers. Meanwhile, the most common use is probably as a strong cation exchanger (SCX) for the amine “Catch and Release” purification technique in SPE cartridges.
Supported sulfonic acids such as SiliaBond® Propylsulfonic Acid (SiliaBond SCX-2) are in a class of strong acids widely used in different fields of synthetic organic chemistry. Their applications are well known and are used in a large number of settings going from drug discovery laboratories up to manufacturing processes. Among these applications, we denote their uses as acid catalysts, stationary phases for ion chromatography and basic impurity scavengers. Meanwhile, the most common use is probably as a strong cation exchanger (SCX) for the amine “Catch and Release” purification technique in SPE cartridges.
SiliaBond® Amine (Si-NH2) is an effective scavenger of acid chlorides, sulfonyl chlorides, isocyanates and other electrophiles. Si-NH2 has been shown to be effective metal scavenger and catalyst for Knoevenagel reactions. SiliaBond Amine is also used in chromatography as normal phase sorbent.
SiliaBond® Allyl (Si-Allyl) can be used as solid support for further derivatization.
SiliaBond® Bromophenyl (Si-BRP) can be used as solid support for further derivatization.
SiliaBond® Propyl Bromide (Si-PBR) is a versatile solid support for amines and alcohols. It is more reactive than the chloride towards displacement.
SiliaBond® Phenylmethylchloride (Si-PMC) can be used as solid support for further derivatization.
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