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SiliaBond®- Bases

In order to simplify the use and the removal of bases and their salts from reaction mixtures, SiliCycle has developed a range of silica bound SiliaBond bases :

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  1. SiliaBond® Pyridine

    SiliaBond® Pyridine

    SiliaBond Pyridine (Si-PYR) can be used as a tertiary amine for acid removal. It can also anchor Cu2+ ions and then be used as a catalyst for hydroquinone oxidation.

  2. SiliaBond® Dimethylamine

    SiliaBond® Dimethylamine

    SiliaBond® Dimethylamine is a silica bound tertiary amine base that can be used in most applications requiring a tertiary amine, particularly as a HCl sponge. Silica bound ammonium salt by-products are easily separated by filtration. This dimethylamine immobilized on silica gel can be used as a base catalyst in Michael or Knoevenagel reactions.

  3. SiliaBond® Amine nec

    SiliaBond® Amine nec

    SiliaBond® Amine (Si-NH2) is an effective scavenger of acid chlorides, sulfonyl chlorides, isocyanates and other electrophiles. Si-NH2 has been shown to be effective metal scavenger and catalyst for Knoevenagel reactions. SiliaBond Amine is also used in chromatography as normal phase sorbent.

  4. SiliaBond® Piperazine

    SiliaBond® Piperazine

    SiliaBond® Piperazine (Si-PPZ) is a useful deprotecting and scavenging agent for Fmoc1 and Bsmoc2 amino protecting groups and as a solid-phase Knoevenagel catalyst. According to the results of a study1, Si-PPZ is superior to its polystyrene-based equivalent. SiliaBond Piperazine may also be used to scavenge electrophiles.


  5. SiliaBond® Tosyl Hydrazine

    SiliaBond® Tosyl Hydrazine

    SiliaBond® Tosyl Hydrazine (Si-TsNHNH2) is an effective scavenger of carbonyl compounds. It has been used to selectively remove aldehydes in the presence of ketones since the scavenging of ketones requires an acid catalyst. Once bound, sulfonyl hydrazones can be utilized in other synthetic transformations.

  6. SiliaBond® Carbonate

    SiliaBond® Carbonate

    SiliaBond® Carbonate (Si-CO3) is the silica bound equivalent of tetramethyl ammonium carbonate. It can be used as a general base to quench a reaction, to free base amines in their ammonium salt form and to scavenge acids and acidic phenols, including HOBt, which is widely used in amide coupling reactions.

  7. SiliaBond® Morpholine

    SiliaBond® Morpholine

    SiliaBond® Morpholine (Si-MOR) is commonly used as an acid sponge. It is used in the same manner as morpholine functionalized polymers.

  8. SiliaBond® Piperidine

    SiliaBond® Piperidine

    SiliaBond® Piperidine (Si-PIP) is a general purpose tertiary amine base to scavenge acids, thereby avoiding salt elimination problems. Also used as a base catalyst for Knoevenagel condensation.

  9. SiliaBond® DMAP

    SiliaBond® DMAP

    SiliaBond® DMAP (Si-DMAP) is the supported equivalent of 4-dimethylaminopyridine commonly used as a nucleophilic catalyst in a wide variety of reactions such as acylation, amidation or acetylation.

  10. SiliaBond® Diethylamine

    SiliaBond® Diethylamine

    SiliaBond® Diethylamine (SiliaBond WAX-2) is a silica bound tertiary amine base and can be used in most applications requiring a tertiary amine, particularly as a HCl sponge. Silica bound ammonium salt by-products are easily separated by filtration. This diethylamine immobilized on silica gel can be used for the same applications as SiliaBond Dimethylamine. It is a very common supported tertiary amine.

  11. SiliaBond® Base Kit

    SiliaBond® Base Kit

    Amine - Carbonate - Dimethylamine - Diethylamine - Morpholine - Pyridine - Guanidine
  12. SiliaMetS® Triamine

    SiliaMetS® Triamine

    SiliaMetS® Triamine (SiliaMetS WAX-3, Si-TRI) is effective for scavenging metals such as Pb, Co, Ru and Pd. Our screening studies have shown it to be the preferred scavenger for Pb. It can also be used as a scavenger for acid chlorides, isocyanates and other electrophiles.

  13. SiliaMetS® Diamine

    SiliaMetS® Diamine

    SiliaMetS® Diamine (Si-DIA) is a proven scavenger for metals and electrophiles. It scavenges acids, acid chlorides, anhydrides, aldehydes, isocyanates, and chloroformates as well as Pb, Ni, and Cd.

  14. SiliaBond® Amine

    SiliaBond® Amine

    SiliaBond® Amine (Si-NH2) is an effective scavenger of acid chlorides, sulfonyl chlorides, isocyanates and other electrophiles. Si-NH2 has been shown to be effective metal scavenger and catalyst for Knoevenagel reactions. SiliaBond Amine is also used in chromatography as normal phase sorbent.

  15. SiliaMetS® Imidazole

    SiliaMetS® Imidazole

    SiliaMetS® Imidazole (Si-IMI) is a versatile metal scavenger for a variety of metals including Cd, Co, Cu, Fe, Ni, Pd, and Rh under a wide range of conditions and the preferred metal scavenger for iron catalysts.

    SiliaMetS Imidazole can also be used as an amine base in systems that are generally sensitive to basic conditions compared to other SiliaMetS supported bases.

  16. SiliaPrep™ SPE Cartridges Amine (WAX)

    SiliaPrep™ SPE Cartridges Amine (WAX)

    SiliaPrep Amine is a weak anion exchanger sorbent used in replacement of SAX for strong anions to avoid irreversible retention. Can also be employed as a metal scavenger and in normal phase conditions.

  17. SiliaPrep™ SPE Cartridges Amine nec (WAX)

    SiliaPrep™ SPE Cartridges Amine nec (WAX)

    SiliaPrep Amine nec is a weak anion exchanger sorbent used in replacement of SAX for strong anions to avoid irreversible retention. Can also be employed as a metal scavenger and norman phase conditions.

  18. SiliaPrep™ SPE Cartridges Piperazine (SPE-R60030B)

    SiliaPrep™ SPE Cartridges Piperazine (SPE-R60030B)

    SiliaPrep Piperazine is a weak anion exchanger that can be used in replacement of SAX and SAX-2 for strong anions to avoid irreversible retention. By using this phase, elution can be done at a lower pH (around pH 8-9) comparatively to the SiliaPrep Amine.

  19. SiliaPrep™ SPE Cartridges Diethylamine (WAX-2)

    SiliaPrep™ SPE Cartridges Diethylamine (WAX-2)

    SiliaPrep Diethylamine (WAX-2) is a weak anion exchanger that can be used in replacement of SAX and SAX-2 for strong anions to avoid irreversible retention. This phase presents a slightly lower capacity and a moderate non polar character due to the alkyl chain on the amino function. Moreover, it can be employed as metal scavenger and in normal phase conditions.

  20. SiliaPrep™ SPE Cartridges Carbonate

    SiliaPrep™ SPE Cartridges Carbonate

    SiliaPrep Carbonate (or Si-CO3) is the silica bound equivalent of tetramethyl ammonium carbonate. It can be used as a general base to quench a reaction, to free base amines in their ammonium salt form and to scavenge acids, boronic acids and acidic phenols, including HOBt, which is widely used in amide coupling reactions.

  21. SiliaPrep™ SPE Cartridges Diamine

    SiliaPrep™ SPE Cartridges Diamine

    SiliaPrep Diamine can be used in replacement of SAX for strong anions. It can also be employed as metal scavenger and in normal phase conditions.

  22. SiliaPrep™ SPE Cartridges Diamine nec

    SiliaPrep™ SPE Cartridges Diamine nec

    SiliaPrep diamine can be used in replacement of SAX for strong anions to be irreversible retention. Can also be employed as metal scavenger and in normal-phase conditions.

  23. SiliaPrep™ SPE Cartridges Triamine

    SiliaPrep™ SPE Cartridges Triamine

    SiliaPrep Metal Scavengers will lower the residual metal concentration of various metal complexes to single digit ppm.

  24. SiliaPrep™ 96 Well Plates Amine

    SiliaPrep™ 96 Well Plates Amine


    Standard SiliaPrep 96 Well Plates are available in 2 mL with different bed weight up to 200 mg. Various sorbents are available and are divided into several sections based on sorbent characteristics.
  25. SiliaPrep™ 96 Well Plates Amine nec

    SiliaPrep™ 96 Well Plates Amine nec


    Standard SiliaPrep 96 Well Plates are available in 2 mL with different bed weight up to 200 mg. Various sorbents are available and are divided into several sections based on sorbent characteristics.
  26. SiliaPrep™ 96 Well Plates Carbonate

    SiliaPrep™ 96 Well Plates Carbonate


    Standard SiliaPrep 96 Well Plates are available in 2 mL with different bed weight up to 200 mg. Various sorbents are available and are divided into several sections based on sorbent characteristics.
  27. SiliaPrep™ 96 Well Plates Diethylamine (WAX-2)

    SiliaPrep™ 96 Well Plates Diethylamine (WAX-2)


    Standard SiliaPrep 96 Well Plates are available in 2 mL with different bed weight up to 200 mg. Various sorbents are available and are divided into several sections based on sorbent characteristics.

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