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- > It’s not just about the shape – Handy guide to (other) common problems in HPLC
- > How to get the perfect shape according to experts – Top 6 most common shape problems in HPLC
- > Some People Excel at Scaling Up Their Purifications and Some Don’t, Which One Are You?
- > Loading in Progress – Avoiding loading capacity mistakes
Product Blog
Gain insight into the world of purification with this collection of articles
It’s not just about the shape – Handy guide to (other) common problems in HPLC
Thursday, April 21, 2022 2:12:18 PM America/New_York
Not everything is about shape when it comes to chromatograms. To get faster and more confident at troubleshooting your HPLC technique, you need to learn how to recognize other indicators that tell you when there is a problem. Read More
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By SiliCycle
How to get the perfect shape according to experts – Top 6 most common shape problems in HPLC
Wednesday, April 20, 2022 3:59:03 PM America/New_York
Before getting into the six most common shape problems, it is important to know why it matters. If a peak becomes too broad or its tail is too large, it might overlap with or hide another peak. In the case of preparative chromatography, this also means mixed fractions are collected. Read More
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Some People Excel at Scaling Up Their Purifications and Some Don’t, Which One Are You?
Friday, April 1, 2022 9:20:52 AM America/New_York
As everyone in R&D knows, pharmaceutical process scalability can be challenging and stressful. Now that I know better, I am sharing how to excel at scaling-up purifications and eliminate the concerns of having large scales results mirroring those from the lab bench. Read More
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Loading in Progress – Avoiding loading capacity mistakes
Friday, March 4, 2022 9:31:54 AM America/New_York
With flash chromatography, you either want to yield a large quantity of product or you want it extremely pure. When both are simultaneously true, a large loading capacity is your best friend. It simplifies the purification of all your crude product in a single run, with high yield and high purity. So, what exactly is loading capacity? Read More
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Loading in progress – Techniques for Successful Sample Loadings
Friday, March 4, 2022 9:31:48 AM America/New_York
Every researcher has their own shortcuts to make things easier and faster in the lab. Unfortunately, when it comes to running flash separations, most of the time there is no way to be sneaky and just load the sample without considering the options and still results in a good separation. And the little of the time it does work, is a lot of luck. Sample load is one of those traps that make us lose more time and energy (and money) neglecting the loading aspect of chromatography. Read More
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The secrets of the Certificates of Analysis revealed
Monday, January 10, 2022 10:37:55 AM America/New_York
In industry, the most common way to demonstrate consistent quality from the product you are getting from the manufacturer is with the Certificate of Analysis (also known as COA or a CofA) Read More
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Troubleshooting for Thin Layer Chromatography
Wednesday, December 8, 2021 2:54:43 PM America/New_York
Thin layer chromatography (TLC) sounds like a relatively simple process. However, in practice, separating the different components can be surprisingly tricky... Read More
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Green Chemistry: Reduce Your Solvent Consumption and Waste Generation During Separations
Friday, November 12, 2021 2:22:53 PM America/New_York
Based on a proactive approach to pollution prevention, the concept, which has evolved with the increased awareness of the effects of chemical contaminants on the planet's health, is revolutionizing industrial chemistry. Read More
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How to Solve Common Challenges in Solid-Phase Extraction
Monday, October 18, 2021 3:38:42 PM America/New_York
Sample preparation is the under-appreciated workhorse of the analytical chemistry lab. In fact, 60-80% of an analyst’s time is devoted to this! Selecting the most appropriate sample preparation tools for analysis and understanding the proper techniques in addition to common challenges are well worth an analyst’s investment of time. Read More
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How to Streamline Metal Scavenger Scale-Up During Drug Development
Monday, September 20, 2021 3:38:28 PM America/New_York
Customers and process scientists have concerns about the scalability of metal scavengers for drug synthesis – a topic we’ve touched on before in other posts but haven’t yet fully explored... Read More
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By SiliCycle