Product Blog

Not everything is about shape when it comes to chromatograms. To get faster and more confident at troubleshooting your HPLC technique, you need to learn how to recognize other indicators that tell you when there is a problem. Read More

Before getting into the six most common shape problems, it is important to know why it matters. If a peak becomes too broad or its tail is too large, it might overlap with or hide another peak. In the case of preparative chromatography, this also means mixed fractions are collected. Read More

As everyone in R&D knows, pharmaceutical process scalability can be challenging and stressful. Now that I know better, I am sharing how to excel at scaling-up purifications and eliminate the concerns of having large scales results mirroring those from the lab bench. Read More

With flash chromatography, you either want to yield a large quantity of product or you want it extremely pure. When both are simultaneously true, a large loading capacity is your best friend. It simplifies the purification of all your crude product in a single run, with high yield and high purity. So, what exactly is loading capacity? Read More

Every researcher has their own shortcuts to make things easier and faster in the lab. Unfortunately, when it comes to running flash separations, most of the time there is no way to be sneaky and just load the sample without considering the options and still results in a good separation. And the little of the time it does work, is a lot of luck. Sample load is one of those traps that make us lose more time and energy (and money) neglecting the loading aspect of chromatography. Read More

In industry, the most common way to demonstrate consistent quality from the product you are getting from the manufacturer is with the Certificate of Analysis (also known as COA or a CofA) Read More

Thin layer chromatography (TLC) sounds like a relatively simple process. However, in practice, separating the different components can be surprisingly tricky... Read More

Based on a proactive approach to pollution prevention, the concept, which has evolved with the increased awareness of the effects of chemical contaminants on the planet's health, is revolutionizing industrial chemistry. Read More

Sample preparation is the under-appreciated workhorse of the analytical chemistry lab. In fact, 60-80% of an analyst’s time is devoted to this! Selecting the most appropriate sample preparation tools for analysis and understanding the proper techniques in addition to common challenges are well worth an analyst’s investment of time. Read More

Customers and process scientists have concerns about the scalability of metal scavengers for drug synthesis – a topic we’ve touched on before in other posts but haven’t yet fully explored... Read More